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Monday, March 25, 2013
Beyond the Grave, Onto the Smartphone
A cemetery in Shenyang, the capital of China's Liaoning Province, will become, for lack of a better term, interactive. With mobile devices, people will be able to scan a quick response code on graves of people whose relatives have requested the feature. Scanning this code will allow visitors to learn about the person's life; they can also access a Web page where relatives and friends can upload photos or video.
How to Go Out and Talk About Your Book | Writing and Publishing ...
It?s common for me to get questions from authors. And it?s interesting to see how the nature of the questions have changed over the years. It used to be that hopeful authors asked, ?How do I find a publisher?? ?Do I need an agent?? ?What publisher/agent would you recommend?? ?How do you write a query letter??
There was a period when I got a lot of questions related to writing a book proposal, identifying genre, copyright and so forth.
Lately, I seem to be getting questions about marketing. ?How do I prepare a marketing plan?? ?What?s the best way to promote a book?? ?How do I promote my ebook?? And today, I got a question from a Toastmaster about how to start going out and speaking about your book.
Of course, I told this author about my latest freebie??50 Ways To Sell Books Through Your Personality.? http://www.patriciafry.com
And I told him about my latest book?Talk Up Your Book, How to Sell Books Through Public Speaking, Interviews, Signings, Festivals, Conferences and More. This book is available at amazon.com and most other online and downtown bookstores. It is in print, on Kindle and audio.
Talk Up Your Book offers up step-by-step assistance for anyone who is eager to start selling books by personally addressing his/her audience as well as those who are terrified of public speaking or anything that resembles it. The book covers stage fright, noodle knees and the whole lack of confidence scenario for reluctant speakers whether you are the author of a nonfiction book, a novel or a children?s book. And it is a no-nonsense guide for those who know that public speaking is an excellent mode of book promotion.
My best advice for a new author who wants to get out in public and promote his or her book, but who isn?t accustomed to it or who is reluctant is this:
1: Begin stepping out into the limelight. Take it slow, if you want. Volunteer to head a committee at work, your club or church so that you get the opportunity to speak before a group. Join a Toastmasters club near you and participate. Join a storytelling or even drama group. Take a speaking course at a local college. Practice, practice, practice.
2: Talk about your book everywhere you go. Come up with a short spiel describing your book and share it often with people you meet at work, socially and in passing. Listen to their questions?these are the things your future audiences will want to know about your book. Make note to weave this information into your speeches when you start writing them.
3: Create a presentation that you would be comfortable presenting to a small group. It should involve an aspect of your book that you know well, are excited about and can convey to others fairly effortlessly. Use some of the notes you?ve collected reflecting some of the questions people have asked about your story, the writing of it or the information in your nonfiction book, for example.
4: Go in search of your ideal audience whether it is children during story time at a local library, civic group members during their monthly lunch meeting, your church auxiliary members, history buffs convening at the museum for docent training, a meeting of businessmen or women or a book club, for example. Contact the program chair and set up a date to speak.
Fill in the blanks?how to write a speech, how to prepare for a presentation, how to create rapport with your audience, radio interviews, getting people to attend your signing, ideas for unusual venues, great introductions to your speeches, how to rehearse your speech, tips for talking about your novel and so much more by reading Talk Up Your Book.
Source: http://www.matilijapress.com/publishingblog/?p=2653
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How would you change LG's Optimus L7?
When we placed LG's Optimus L7 into the palm of our reviewer, they found the handset to be stylish, with a cracking display, excellent battery life and a (then) up-to-date version of Android. Sadly, the party ended after that -- with sluggish internals that can't cope with the company's UI tweaks, weak touchscreen and a lackluster camera. But we're fairly sure our review didn't dissuade all of you from buying one of these, so to those people we ask the following: what, if you were Mr. and Mrs. LG, would you have done differently?
Filed under: Cellphones, Mobile, LG
Source: http://www.engadget.com/2013/03/25/hwyc-lg-optimus-l7/
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International roundup: New Sony phones, our HTC One review and Galaxy S4 chips
In the week that we reviewed the new HTC One, there was quite the gathering of competing stories from other major manufacturers. Samsung dropped a Snapdragon 600-shaped bomb on chipset-conscious UK fans. Sony finally took the wraps off its interesting new mid-ranger, the Xperia SP. And the LG Nexus 4 showed its face once again in the UK and Germany.
Check out some of the bigger international Android stories of the week after the break.
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Source: http://feedproxy.google.com/~r/androidcentral/~3/3jprvhZ3YFo/story01.htm
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Sunday, March 24, 2013
Indiana holds off Temple 58-52 to reach Sweet 16
DAYTON, Ohio (AP) ? Indiana's season, the one that's supposed to finish with confetti falling and nets coming down, was minutes from ending in shock and disappointment.
The Hoosiers were on the brink.
As the clock ticked down, coach Tom Crean wouldn't allow himself to thing about defeat, so his mind wandered elsewhere.
"That's when you just pray," he said.
Request answered.
Victor Oladipo hit a 3-pointer with 14 seconds remaining and the top-seeded Hoosiers, unable to stop Temple star Khalif Wyatt for most of the game, shut him down in the final three minutes for a 58-52 win on Sunday in the East Regional.
Trailing by four with 2:56 left, the Hoosiers (29-6) closed with a 10-0 run and advanced to the round of 16 for the second straight year. After stopping to tell Temple's players they're as good as any Big Ten team, Crean, his red tie askew and his hair messed, was overcome by emotion.
"That," he said, "was relief."
Indiana, with its sights set on a sixth national championship, will play No. 4 seed Syracuse in the regional semifinals on Thursday in Washington, a rematch of the classic 1987 title game won by the Hoosiers.
Wyatt scored 31 points to lead the Owls (24-10), who for 37 minutes gave top-seeded Indiana all it could handle before collapsing when it mattered most.
"We competed really hard," Wyatt said. "We battled. A couple plays here and there, we win. It was just a tough battled game, and they came out on top."
Oladipo, who drew the assignment of chasing Wyatt around the floor and needed plenty of help from his teammates, scored 16 and Cody Zeller added 15 for the Hoosiers, the regular-season Big Ten champs.
"If they were in our league, they'd be fighting for a championship too," Crean said. "I don't think there's any doubt about that. They're that good."
After Oladipo's long 3 put the Hoosiers up 56-52, Indiana had to buckle down on Wyatt, the Atlantic 10's Player of the Year. Wyatt was way off with a 3-pointer from the right wing with six seconds left and Indiana's Christian Watford grabbed the rebound and was fouled.
With his hands on his hips, Wyatt walked dejectedly up the floor as Dayton Arena rocked and the senior pounded his chest. The Hoosiers? heartbeats finally slowed. On Saturday, Gonzaga became the first No. 1 seed to be knocked off and, until Wyatt's miss, Indiana was in danger of zigging with the Zags.
Instead, Indiana will pack up and head to the nation's capital and a homecoming for Oladipo, who is from Upper Marlboro, Md. The junior will get to play in front of family and friends. Most importantly, he'll get to play.
"It's a great feeling," Oladipo said. "I'm just glad that we're going."
After Watford, who earlier made a huge block on Anthony Lee with Indiana trailing 52-50, hit two free throws to seal the win, the red-and-white-clad Indiana faithful relaxed and celebrated much the way Big Ten brethren Ohio State did earlier, when Aaron Craft's 3-pointer in the final second beat Iowa State and pushed the Buckeyes ahead in the West Regional.
Wyatt nearly turned this tournament into his national coming-out party. Despite playing with an injured left thumb, Wyatt, who also scored 31 in the opener against North Carolina State, gave the Hoosiers fits. With the score tied at 52-all, he broke free from Oladipo, but missed a 3-pointer and Indiana got the rebound.
Oladipo was fouled, and during a stop in action, Wyatt stared at the ball at his feet and yelled in frustration. Oladipo split a pair of free throws, but he was able to keep the ball from Wyatt on Temple's next trip, which ended when Rhalir Hollis-Jefferson's contested shot missed everything.
Then, with Indiana needing a score to open some breathing room, Oladipo hit a shot Hoosier fans will add to the pantheon of big ones by IU players.
"I was just open, and I shot it," Oladipo said, downplaying his heroics.
Indiana senior Jordan Hulls, who has played in more games for the Hoosiers than any other player, returned in the second half with a protective wrap on an injured right shoulder. He knocked down a 3 with 8:49 left to pull the Hoosiers within 41-40 and give Indiana's fans something to do other than complain about the officiating.
Scoring from inside and out, and looking into the crowd after every made shot, Wyatt had 20 points in the first half. And although he missed a 3-pointer in the final second, the senior clapped his hands and let out a high-pitched "whoooop" as he headed to the locker room with the Owls leading 29-26.
The three-point deficit at the break matched Indiana's largest this season, and the Hoosiers hardly looked like themselves for much of the opening 20 minutes.
But in the second half, Indiana used Oladipo, Remy Abell, Sheehey and even Zelller on Wyatt, who found it much more difficult to get to the basket ? or even an unobstructed look at it.
"It was fun while it lasted," he said.
The Hoosiers' good times roll on.
Kentucky had barely finished cutting down the nets as national champions last year in New Orleans, when Indiana, which lost to the Wildcats in the tournament, were labeled as the team to beat in 2013. They embraced the higher expectations, and led by seniors Hulls and Watford ? who were around when IU bottomed out amid scandal ? the Hoosiers spent most of this season at or near the top of the AP Top 25. Indiana took a few lumps in the brutal Big Ten, but handed out just as many in winning its first regular-season conference title since 1993.
Nice, but not close to the ultimate goal ? a national championship. That's still in front of the Hoosiers.
"We're on a mission," Oladipo said.
Source: http://news.yahoo.com/indiana-holds-off-temple-58-52-reach-sweet-211829424--spt.html
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Historic lunch: Pope meets (ex) pope
AP
Pope Francis, left, and Pope emeritus Benedict XVI pray together in Castel Gandolfo Saturday, in this photo provided by the Vatican paper L'Osservatore Romano.
By Claudio Lavanga and Emma Ong, NBC News
Pope Francis and his predecessor Benedict prayed together before having lunch in a historic meeting Saturday.
The new pontiff flew to the papal residence at Castel Gandolfo in the Alban Hills outside of Rome by helicopter Saturday. Pope Benedict XVI has been living there since he resigned Feb. 28, becoming the first pope to step down in 600 years.
Both men wore white papal outfits.
Father Federico Lombardi, a Vatican spokesman, said that Benedict and Francis had embraced at the helipad, then went to a private chapel to pray.
Pope Francis met with his predecessor Pope emeritus Benedict XVI today at Castel Gandolfo outside of Rome. NBC's Claudio Lavanga reports.
Benedict, who looked frail and walked with a cane, told Francis to kneel in front of the altar, but Francis said, "let's kneel together" and they did so, Lombardi said.
"We're brothers," Francis reportedly told the former pope as the two prayed together on the same prie dieu.
They then had a private conversation for about 40 minutes in the library, before going to lunch.
Francis presented Benedict with a gift of an icon of the Virgin Mary.
?When I saw this picture of the Madonna of Humility, my thoughts turned immediately to you,? Francis told his predecessor, according to Eurovision News.
The Associated Press reported that crowds gathered near then villa in the hope of catching a glimpse of history.
The news agency speculated about what the two men would discuss:
The two popes might discuss the big issues facing the church: The rise of secularism in the world, the drop in priestly vocations in Europe, the competition that the Catholic Church faces in Latin America and Africa from evangelical Pentecostal movements.
They might also discuss pressing issues concerning Francis' new job: Benedict left a host of unfinished business on Francis' plate, including the outcome of a top-secret investigation into the leaks of papal documents last year.
Francis might want to sound Benedict out on his ideas for management changes in the Holy See administration, a priority given the complete dysfunctional government he has inherited.
They might also discuss the future of Monsignor Georg Gaenswein, Benedict's trusted aide who has had the difficult task of escorting his old pope into retirement and then returning to the Vatican to serve his successor.
Gaenswein has appeared visibly upset and withdrawn at times as he has been by Francis' side. The Vatican has said Francis' primary secretary will be Monsignor Alfred Xuereb, who had been the No. 2 secretary under Benedict.
NBC News' Ian Johnston and The Associated Press contributed to this report.
Related:
Pope Francis spoke of being 'dazzled' by girl, possible change of celibacy rule
Pope stuns newsstand owner by calling to cancel home delivery
Pope's personal touch with crowds a 'nightmare' for security, expert says
This story was originally published on Sat Mar 23, 2013 7:56 AM EDT
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Saturday, March 23, 2013
Blocking an inflammation pathway prevents cardiac fibrosis, study suggests
Mar. 21, 2013 ? New research from UC Davis published in the Proceedings of the National Academy of Sciences shows that blocking an enzyme that promotes inflammation can prevent the tissue damage following a heart attack that often leads to heart failure.
Led by Nipavan Chiamvimonvat, cardiologist and professor of internal medicine, a team of researchers tested a compound that inhibits the enzyme soluble epoxide hydrolase -- or sEH -- one of the key players in the robust immune-system response that heals tissue following an injury. The enzyme, however, can become counterproductive after a cardiac event.
Chiamvimonvat explained that sEH increases proinflammatory lipid mediators, leading to long-term, heightened inflammatory conditions. It also causes cells, which typically link together and provide the foundation for heart tissue, to overwork. The outcome is scar tissue, or fibrosis, that results in an abnormal relaxation of the heart after each beat, taxing remaining heart muscle as it performs double duty and eventually leading to a decline in the heart's pumping action.
"We often see patients following a heart attack in clinic who initially respond well to current treatments, which address the initial causes of the cardiac event and try to preserve heart function," said Chiamvimonvat, whose research focuses on the biological mechanisms of heart disease. "Over time, though, heart function in some patients continues to worsen and can lead to heart failure. It would be ideal to have new approaches that target the cellular overproduction that leads to heart muscle stiffening and cardiac fibrosis."
Heart failure progressively limits oxygen throughout the body, reducing mobility, respiration and quality of life. According to the Centers for Disease Control and Prevention, the condition affects 5.7 million people in the U.S. and costs the nation $34.4 billion in health-care services, medications and lost productivity. About half of people who have heart failure die within five years of diagnosis.
Previous research by Chiamvimonvat showed that an sEH inhibitor synthesized in the laboratory of entomology Professor Bruce Hammock can reduce the enlargement of heart muscle cells and associated arrhythmia. For the current study, she conducted a series of experiments to determine if it could also be a potential treatment for fibrosis.
Chiamvimonvat and her team tested the compound on a mouse model for heart attack. Because cardiac fibrosis can also be caused by other long-term cardiac diseases, the compound was also used on a mouse model for the chronic pressure overload commonly seen with hypertension. For both models, one group of mice was given the compound with their drinking water, while another group was not. The animals' heart functions were assessed using echocardiography.
The results showed that the mice receiving treatment had significant decreases in adverse cardiac muscle remodeling following a heart attack or due to chronic pressure overload. Their overall cardiac function also improved. Additional tests performed in Hammock's lab showed significantly reduced inflammatory factors in their systems.
"Our study shines new light on this inflammation pathway and identifies a potential therapeutic target that could greatly expand options for one of the biggest and most difficult-to-treat problems in cardiology," said Javier Lopez, cardiologist, assistant professor of internal medicine and study co-author who developed methods used in the study to quantify fibrotic cells.
The team hopes to test the compound next on a larger animal model as a precursor to human clinical trials.
"This project is part of a long-term, exciting collaboration between two labs dedicated to combining their strengths to benefit human health," said Hammock. "The translational value of our research is significant."
The study received major support from the National Institutes of Health (grant HL85727 and HL85844), a Veterans Administration Merit Review Grant, the Howard Hughes Medical Institute Med-into-Grad Training Program, an NIH-funded Training Grant in Basic and Translational Cardiovascular Science (grant T32 HL86350), the American Heart Association, a Western States Affiliate Predoctoral Fellowship Award, a Fellow-to-Faculty Award from the Sarnoff Cardiovascular Research Foundation and a Harold Amos Medical Faculty Development Award from the Robert Wood Johnson Foundation.
Partial support was provided by the National Institute of Environmental Health (grant R37 ES01710), the NIEHS Superfund Basic Research Program (grant P42 ES04699), the NIEHS Center for Children's Environmental Health and Disease Prevention (grant P02 ES11269), a Technology Translational Grant from UC Davis Health System and the American Asthma Society. Hammock is a George and Judy Marcus Senior Fellow of the American Asthma Society. Chiamvimonvat is also affiliated with the VA Northern California Healthcare System.
Additional UC Davis study authors were Padmini Sirish, Ning Li, Jun-Yan Liu, Kin Sing Stephen Lee, Sung Hee Hwang, Hong Qiu and Siu Mei Ma. Author Cuifen Zhao is currently at Shandong University in China.
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The above story is reprinted from materials provided by University of California - Davis Health System.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- P. Sirish, N. Li, J.-Y. Liu, K. S. S. Lee, S. H. Hwang, H. Qiu, C. Zhao, S. M. Ma, J. E. Lopez, B. D. Hammock, N. Chiamvimonvat. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1221972110
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/-HV2rkVsnho/130322104304.htm
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